Research 4 | Beckstein Lab

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A two-domain elevator mechanism for sodium/proton antiport

A two-domain elevator mechanism for sodium/proton antiport

In a combined X-ray crystallography/biochemistry/molecular simulation study published in Nature we present the structure of the sodium/proton antiporter NapA in its outward facing conformation. Together with the inward facing conformation of the related transporter NhaA we can now understand the conformational changes required for the sodium/proton antiport mechanism.

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External publication records

External publication records

Sortable lists of publications are maintained under ResearcherID C-9095-2009 and as a NCBI MyBibliography , whereas Oliver Beckstein’s Google Scholar Profile automatically updates.

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Molecular dynamics simulations

Molecular dynamics simulations

Molecular dynamics (MD) is a computational method to compute the trajectories of a large number of particles that interact with each other. Classical MD approximates interactions between atoms by classical forces but fully quantum mechanical MD has also been carried out. Experimental observables are calculated from trajectories using statistical mechanics.

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