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Influence of lipids on transmembrane transport proteins

Influence of lipids on transmembrane transport proteins

We are reviewing the evidence for direct effects of lipids on the transport properties of ion channels and active transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. For transporters, the evidence is more ambiguous. In all areas, however, the use of computer simulations extends the way in which we understand protein-membrane interactions.

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Lennard van der Feltz

Lennard van der Feltz

Lennard graduated with a Masters of Science in Physics in Fall 2014. His work is concerned with the electrostatics of ion channels and pores. He is primarily using Poisson-Boltzmann calculations to obtain experimentally measurable observables in a semi-quantitative manner.

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Ion channels

Ion channels

Ion channels are membrane proteins that play major roles in fast signal conduction in nerve cells and the brain. They consist of a water filled pore through which ions can flow. An external signal, such as a change in membrane potential or the binding of a neurotransmitter, can switch the pore from “open” to “closed”, a process termed gating.

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