Tag 1 | Beckstein Lab

. . . . .
Tag Archives: ions
APS 4CS Meeting 2017

APS 4CS Meeting 2017

The APS 4 Corners Section Meeting is held annually and will be hosted at Colorado State University on October 20th and 21st. Oliver was invited to present the group’s research on Structure and function of electrogenic sodium/proton antiporter membrane proteins.

Comment Continue Reading →
Bidstrup Foundation Undergraduate Fellowship for Kacey Clark

Bidstrup Foundation Undergraduate Fellowship for Kacey Clark

Physics freshwoman undergraduate student Kacey Clark was selected as a Bidstrup Undergraduate Fellow for the 2016-2017 academic year. The Bidstrup Fellowship is awarded by Barrett, The Honors College at Arizona State University where Kacey is a student.

Comment [1] Continue Reading →
Molecular basis of ion translocation in sodium/proton antiporters

Molecular basis of ion translocation in sodium/proton antiporters

We studied the process of sodium/proton antiport in the NapA transporter. Through a combination of X-ray crystallography, biochemistry and computer simulations we could show that the antiporter undergoes a large conformational transition that resembles a *elevator*-like movement whereby a single domain moves up- and down through the membrane and carries a sodium ion with it.

Comment Continue Reading →
Project: Transport of divalent cations

Project: Transport of divalent cations

Divalent cations such as zinc or magnesium are essential for living organisms but the mechanisms by which they are transported into and out of the cell are not well understood at the molecular level. Classical molecular dynamics simulations of divalent ions are challenging because the high electric field strength near the ion leads to polarization effects that are not accurately accounted for in standard MD force fields. In this project you will explore alternative models for simulating divalent ions in order to find models that combine computational speed with sufficient accuracy to study transport of divalent ions with transporter proteins.

Comment Continue Reading →