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Tag Archives: napa
APS 4CS Meeting 2017

APS 4CS Meeting 2017

The APS 4 Corners Section Meeting is held annually and will be hosted at Colorado State University on October 20th and 21st. Oliver was invited to present the group’s research on Structure and function of electrogenic sodium/proton antiporter membrane proteins.

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Molecular basis of ion translocation in sodium/proton antiporters

Molecular basis of ion translocation in sodium/proton antiporters

We studied the process of sodium/proton antiport in the NapA transporter. Through a combination of X-ray crystallography, biochemistry and computer simulations we could show that the antiporter undergoes a large conformational transition that resembles a *elevator*-like movement whereby a single domain moves up- and down through the membrane and carries a sodium ion with it.

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Becksteinlab featured in A2C2 Quarterly

Becksteinlab featured in A2C2 Quarterly

The work in the lab was featured in the Winter 2014 edition of the A2C2 Quarterly newsletter.

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X-ray crystallography and Simulations

X-ray crystallography and Simulations

Structures of membrane proteins can be obtained by the experimental technique of X-ray crystallography. However, proteins are typically not crystallized in their native environment, the lipid membrane. Molecular dynamics simulations of the protein in the membrane provide a realistic model of the interactions between transporter and lipid bilayer.

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