Lipids category listing 1 | Beckstein Lab

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Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors

Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors

G protein-coupled receptors (GPCRs) make up the largest family of proteins in mammalian cells. These receptors are known to be sensitive to cholesterol in the cellular membrane. Coarse-grained molecular dynamics (CGMD) was used to identify specific protein-cholesterol interaction sites. The analysis showed differential cholesterol binding on equivalent residues in homologues known to have different sensitivities to cholesterol.

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Influence of lipids on transmembrane transport proteins

Influence of lipids on transmembrane transport proteins

We are reviewing the evidence for direct effects of lipids on the transport properties of ion channels and active transporters. For ion channels it has been convincingly shown that specific lipid-protein interactions can directly affect their function. For transporters, the evidence is more ambiguous. In all areas, however, the use of computer simulations extends the way in which we understand protein-membrane interactions.

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